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The Drug Enforcement Administration (DEA) is the organization responsible for registering physicians who prescribe controlled substances. This registration process is crucial because it ensures that only qualified healthcare providers can prescribe medications that have the potential for abuse or dependency. The DEA regulates the manufacture and distribution of these substances to maintain control over their use and to prevent misuse in society.

The other organizations mentioned serve different roles within the healthcare system. The Food and Drug Administration (FDA) regulates the safety and efficacy of medications but does not handle the registration of prescribers. The American Medical Association (AMA) focuses on advancing the interests of physicians and the medical profession, providing guidelines and support rather than regulatory oversight. The Centers for Disease Control and Prevention (CDC) primarily deals with public health initiatives and disease prevention but does not oversee the prescribing of medications. Therefore, the DEA is specifically tasked with the responsibility of overseeing controlled substance prescriptions.